Regulation of response to reactive oxygen species

Across TCGA cell cohorts, RNA activity of the Regulation of response to reactive oxygen species pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NRP2, WNT1, and LAMC1, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of response to reactive oxygen species activity versus NRP2 in BLOOD_Leukemia (Pearson r = -0.94).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NRP2 →	-0.617	-2.087	<.001	<.001	3	1
BLOOD_Leukemia	WNT1 →	-0.060	-2.197	.006	<.001	3	1
BLOOD_Leukemia	LAMC1 →	-3.040	-2.087	.004	<.001	3	1
BLOOD_Leukemia	NUMA1 →	+0.875	+2.087	.008	<.001	3	1
BLOOD_Leukemia	FDX1 →	+0.719	+2.087	<.001	<.001	3	1
BLOOD_Leukemia	GPR158 →	-3.539	-2.087	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901031 vs NRP2 — BLOOD_Leukemia

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