Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LDHAP7, CPA4, and FOXK2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway activity versus LDHAP7 in GBM (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LDHAP7 →	+0.330	+0.106	.001	.003	3	5
HNSC	CPA4 →	+1.043	+0.101	.001	<.001	3	4
OV	FOXK2 →	-0.484	-0.154	.001	.002	3	4
BRCA	PGK1P1 →	+0.603	+0.079	.006	.005	3	4
BRCA	RPS3AP13 →	+0.230	+0.104	.003	<.001	3	4
CCRCC	SOGA1 →	-0.510	-0.113	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901029 vs LDHAP7 — GBM

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