Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BAK1, HSPA1A, and MPV17L, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway activity versus BAK1 in KIDNEY (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	BAK1 →	+0.837	+0.172	.001	<.001	3	11
BLOOD_Lymphoma	HSPA1A →	+3.852	+0.125	<.001	<.001	3	11
LIVER	MPV17L →	-1.614	-0.165	<.001	<.001	3	9
OESOPHAGUS	PSMB9 →	+2.466	+0.137	.006	.008	2	10
BONE	MYL6 →	+1.141	+0.187	<.001	<.001	3	8
LIVER	FLNA →	+1.585	+0.159	.004	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901029 vs BAK1 — KIDNEY

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