Regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPS5, RTN1, and TOM1_S160, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway activity versus RPS5 in OV (Pearson r = -0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RPS5 →	-0.274	-0.041	.003	.001	3	4
GBM	RTN1 →	+0.587	+0.043	<.001	<.001	3	4
GBM	TOM1_S160 →	+0.521	+0.041	.006	.002	3	4
GBM	CHGB →	+0.735	+0.030	<.001	<.001	3	4
GBM	CYFIP2 →	+0.324	+0.028	.008	.006	3	4
GBM	DENND4B →	+0.182	+0.039	<.001	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901028 vs RPS5 — OV

Explore this scatter interactively →