Regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLPI, MYO5C, and ITPKC, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLPI grouped by Regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SLPI →	+2.355	+1.165	.009	.006	3	5
STOMACH	MYO5C →	+2.140	+1.601	.004	<.001	3	5
STOMACH	ITPKC →	+1.240	+1.199	.001	<.001	2	6
KIDNEY	OVOL2 →	+0.255	+1.380	.001	.001	3	5
LUNG_NSCLC_LUSC	EPCAM →	+3.576	+1.583	.001	<.001	3	5
LIVER	RASEF →	+2.180	+1.386	.005	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLPI by Regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway activity — OESOPHAGUS

Explore this box plot interactively →