Regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACAA2, TVP23C, and LUC7L3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway activity versus ACAA2 in STOMACH (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ACAA2 →	+2.275	+0.353	<.001	<.001	3	7
LUNG_NSCLC_LUSC	TVP23C →	-1.088	-0.304	<.001	.001	3	5
BONE	LUC7L3 →	-1.167	-0.267	.008	.001	2	6
CNS	DCAF16 →	-0.565	-0.257	.006	<.001	3	5
STOMACH	METAP2 →	-0.503	-0.281	<.001	.001	3	4
SOFT_TISSUE	ANK2 →	+3.005	+0.268	.002	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901028 vs ACAA2 — STOMACH

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