Positive regulation of calcium ion transmembrane transporter activity

pathway activity — cross-omics
GO:1901021Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Positive regulation of calcium ion transmembrane transporter activity pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BCLAF1_S397, TLN1_S1164, and ZRANB2_S153, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMBCLAF1_S397 →-0.258-0.050.006<.00135
COADTLN1_S1164 →-0.453-0.022.007.00835
LUADZRANB2_S153 →-0.190-0.027<.001<.00134
GBMPLCB1 →+0.729+0.050<.001.00334
HNSCANK2_S3845 →+0.948+0.077<.001.00234
HNSCRPL7L1 →-0.290-0.064.003.00734
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration