Negative regulation of calcium ion transmembrane transporter activity

Across TCGA patient cohorts, RNA activity of the Negative regulation of calcium ion transmembrane transporter activity pathway is significantly associated with the RNA expression of multiple genes, with the ACC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF628, CBARP, and TRAF7, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of calcium ion transmembrane transporter activity activity versus ZNF628 in ACC (Pearson r = -0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	ZNF628 →	-0.959	-0.056	<.001	<.001	3	17
MESO	CBARP →	-0.655	-0.057	<.001	<.001	3	16
ACC	TRAF7 →	-1.379	-0.056	<.001	<.001	3	16
ACC	IRF2BP1 →	-0.655	-0.042	<.001	<.001	3	16
ACC	SCRIB →	-1.295	-0.050	<.001	<.001	3	16
THYM	ZNF696 →	-0.483	-0.024	<.001	.002	2	16

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901020 vs ZNF628 — ACC

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