Negative regulation of calcium ion transmembrane transporter activity

Across TCGA patient cohorts, RNA activity of the Negative regulation of calcium ion transmembrane transporter activity pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CLIC2, LCP2, and PSMB10, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of calcium ion transmembrane transporter activity activity versus CLIC2 in HNSC (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CLIC2 →	+0.371	+0.088	.001	<.001	3	8
LSCC	LCP2 →	+0.325	+0.054	<.001	<.001	3	6
LSCC	PSMB10 →	+0.355	+0.071	<.001	<.001	3	6
LSCC	RCSD1 →	+0.330	+0.055	<.001	<.001	3	5
UCEC	SHANK3 →	+0.225	+0.076	.002	.002	3	5
BRCA	WAS →	+0.374	+0.039	<.001	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901020 vs CLIC2 — HNSC

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