Negative regulation of calcium ion transmembrane transporter activity

Across TCGA patient cohorts, RNA activity of the Negative regulation of calcium ion transmembrane transporter activity pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAP1, IFFO1, and SYNE1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of calcium ion transmembrane transporter activity activity versus CAP1 in PDAC (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CAP1 →	-0.352	-0.163	.009	.001	3	4
OV	IFFO1 →	+0.772	+0.159	<.001	.002	3	4
HNSC	SYNE1 →	+0.796	+0.238	<.001	<.001	3	4
HNSC	GIMAP8 →	+1.125	+0.276	<.001	<.001	3	4
BRCA	CCL19 →	+2.148	+0.247	<.001	<.001	3	4
BRCA	ABCD2 →	+0.683	+0.266	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901020 vs CAP1 — PDAC

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