Negative regulation of calcium ion transmembrane transporter activity

Across TCGA cell cohorts, RNA activity of the Negative regulation of calcium ion transmembrane transporter activity pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CALM2, ULK1, and SGK2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CALM2 grouped by Negative regulation of calcium ion transmembrane transporter activity-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CALM2 →	-0.176	-1.028	<.001	.001	3	8
BONE	ULK1 →	-0.118	-1.458	.004	.001	3	6
OVARY	SGK2 →	-0.284	-0.972	.007	.001	2	7
LUNG_NSCLC_LUSC	HTR6 →	-0.249	-1.307	.001	<.001	3	6
BONE	EIF5A2 →	-0.372	-1.657	.004	<.001	3	5
OVARY	DRD3 →	-0.194	-0.910	.003	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CALM2 by Negative regulation of calcium ion transmembrane transporter activity activity — LUNG_SCLC

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