Negative regulation of calcium ion transmembrane transporter activity

Across TCGA cell cohorts, RNA activity of the Negative regulation of calcium ion transmembrane transporter activity pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C1orf167, TFDP2, and TSPAN12, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C1orf167 grouped by Negative regulation of calcium ion transmembrane transporter activity-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	C1orf167 →	+0.820	+0.729	.001	.004	3	4
SKIN	TFDP2 →	+0.845	+0.953	<.001	<.001	3	3
URINARY_TRACT	TSPAN12 →	+2.200	+0.280	.005	.006	3	3
BREAST	FKBP10 →	+3.260	+0.931	.002	<.001	3	3
BREAST	PRICKLE2 →	-1.011	-0.762	.006	.006	2	4
CNS	NBAS →	+0.423	+0.710	.006	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C1orf167 by Negative regulation of calcium ion transmembrane transporter activity activity — KIDNEY

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