Mitochondrial RNA modification

Across TCGA patient cohorts, RNA activity of the Mitochondrial RNA modification pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZC3H8, NAA25, and MDN1, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial RNA modification activity versus ZC3H8 in UVM (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	ZC3H8 →	+1.200	+0.052	<.001	<.001	3	34
UVM	NAA25 →	+1.052	+0.052	<.001	<.001	3	33
TGCT	MDN1 →	+1.161	+0.051	<.001	<.001	3	33
DLBC	MED23 →	+1.215	+0.068	<.001	.001	3	33
UVM	SENP6 →	+1.513	+0.053	<.001	<.001	3	33
UVM	TCERG1 →	+1.517	+0.054	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900864 vs ZC3H8 — UVM

Explore this scatter interactively →