Mitochondrial RNA modification

Across TCGA patient cohorts, RNA activity of the Mitochondrial RNA modification pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SSB, DRG1, and PUS7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial RNA modification activity versus SSB in LSCC (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SSB →	+0.371	+0.061	<.001	<.001	3	6
LSCC	DRG1 →	+0.278	+0.049	<.001	<.001	3	6
LSCC	PUS7 →	+0.435	+0.033	<.001	<.001	3	6
LSCC	WDR75 →	+0.378	+0.039	<.001	<.001	3	6
LSCC	BOP1 →	+0.321	+0.032	<.001	<.001	3	6
LSCC	UTP4 →	+0.336	+0.035	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900864 vs SSB — LSCC

Explore this scatter interactively →