Mitochondrial RNA modification

Across TCGA patient cohorts, RNA activity of the Mitochondrial RNA modification pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS2P7, EIF4EBP1, and TIMM8A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial RNA modification activity versus RPS2P7 in BRCA (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RPS2P7 →	+1.108	+0.190	.003	.005	3	4
OV	EIF4EBP1 →	+0.618	+0.159	.006	<.001	3	4
UCEC	TIMM8A →	+0.453	+0.204	.007	.003	3	4
UCEC	RN7SL123P →	+0.349	+0.172	.006	.003	3	4
BRCA	IPO4 →	+0.094	+0.201	.006	.003	3	4
BRCA	BOP1 →	+0.750	+0.180	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900864 vs RPS2P7 — BRCA

Explore this scatter interactively →