Mitochondrial RNA modification

Across TCGA cell cohorts, RNA activity of the Mitochondrial RNA modification pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD99L2, SPNS1, and MRTFA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CD99L2 grouped by Mitochondrial RNA modification-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CD99L2 →	-1.180	-1.000	<.001	.007	3	4
LUNG_NSCLC_LUAD	SPNS1 →	-0.553	-0.546	.007	.005	3	4
BLOOD_Leukemia	MRTFA →	-0.686	-0.255	.007	.007	3	4
BLOOD_Leukemia	ITPRIPL2 →	-1.294	-0.286	<.001	.001	3	4
KIDNEY	NPIPB13 →	+0.505	+1.205	.004	.003	3	4
CNS	CHST12 →	-0.991	-1.132	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CD99L2 by Mitochondrial RNA modification activity — CNS

Explore this box plot interactively →