Mitochondrial RNA modification

Across TCGA cell cohorts, RNA activity of the Mitochondrial RNA modification pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are METTL8, NCL, and NOP58, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial RNA modification activity versus METTL8 in SOFT_TISSUE (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	METTL8 →	+1.383	+0.124	<.001	<.001	3	19
BLOOD_Lymphoma	NCL →	+1.095	+0.069	<.001	<.001	3	18
BLOOD_Lymphoma	NOP58 →	+1.026	+0.069	<.001	<.001	3	17
BLOOD_Lymphoma	FASTKD2 →	+1.055	+0.073	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	TRMT5 →	+0.898	+0.101	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	HSPD1 →	+1.200	+0.112	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900864 vs METTL8 — SOFT_TISSUE

Explore this scatter interactively →