Mitochondrial RNA modification

Across TCGA cell cohorts, RNA activity of the Mitochondrial RNA modification pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRRD, APOO, and TACC2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial RNA modification activity versus SRRD in LIVER (Pearson r = -0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	SRRD →	-0.918	-1.392	<.001	<.001	3	4
CNS	APOO →	+0.751	+1.199	.007	.002	3	3
LUNG_NSCLC_LUAD	TACC2 →	+1.116	+0.652	.004	.005	3	3
BREAST	ENOSF1 →	-0.762	-0.765	.003	<.001	3	3
BREAST	POLR1E →	-0.934	-0.641	.002	.002	3	3
SKIN	SNRPC →	-0.489	-1.004	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900864 vs SRRD — LIVER

Explore this scatter interactively →