Regulation of membrane depolarization during cardiac muscle cell action potential

Across TCGA patient cohorts, RNA activity of the Regulation of membrane depolarization during cardiac muscle cell action potential pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ANK3, ANK3_S4342, and ANK3_S1459, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of membrane depolarization during cardiac muscle cell action potential activity versus ANK3 in OV (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ANK3 →	+0.660	+0.100	<.001	<.001	3	9
LUAD	ANK3_S4342 →	+1.258	+0.173	.002	.001	3	9
LUAD	ANK3_S1459 →	+0.953	+0.118	<.001	<.001	3	8
LSCC	ANK3_S623 →	+0.894	+0.091	<.001	.009	3	7
GBM	ANK3_S847 →	+0.826	+0.092	<.001	<.001	3	7
CCRCC	ANK3_S959 →	+0.708	+0.117	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900825 vs ANK3 — OV

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