Regulation of membrane depolarization during cardiac muscle cell action potential

Across TCGA patient cohorts, RNA activity of the Regulation of membrane depolarization during cardiac muscle cell action potential pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANK3, ANKDD1B, and HMGB1P41, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of membrane depolarization during cardiac muscle cell action potential activity versus ANK3 in GBM (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ANK3 →	+1.236	+0.620	<.001	<.001	3	9
COAD	ANKDD1B →	+0.579	+0.416	.001	.005	3	5
UCEC	HMGB1P41 →	+0.912	+0.701	.006	.003	3	5
LUAD	ANK3-DT →	+0.595	+0.707	<.001	<.001	3	5
UCEC	ST6GALNAC1 →	+1.164	+0.645	<.001	<.001	3	5
GBM	FAAH →	+0.805	+0.416	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900825 vs ANK3 — GBM

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