Regulation of membrane depolarization during cardiac muscle cell action potential

Across TCGA cell cohorts, RNA activity of the Regulation of membrane depolarization during cardiac muscle cell action potential pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PMCH, CSNK1G3, and TUFT1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of membrane depolarization during cardiac muscle cell action potential activity versus PMCH in LUNG_NSCLC_LUAD (Pearson r = -0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PMCH →	-0.172	-0.346	.001	<.001	3	4
BLOOD_Leukemia	CSNK1G3 →	-1.340	-0.434	.001	.007	3	4
OESOPHAGUS	TUFT1 →	+1.331	+0.311	<.001	<.001	3	3
BLOOD_Lymphoma	HAUS6 →	-1.243	-0.464	.002	.003	3	3
BLOOD_Lymphoma	RSPRY1 →	-0.498	-0.366	.005	<.001	3	3
BLOOD_Leukemia	IBTK →	-0.776	-0.454	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900825 vs PMCH — LUNG_NSCLC_LUAD

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