Positive regulation of vascular endothelial growth factor signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of vascular endothelial growth factor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMOC2, HSPG2, and JCAD, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of vascular endothelial growth factor signaling pathway activity versus SMOC2 in CCRCC (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SMOC2 →	+1.187	+0.086	<.001	.001	3	9
OV	HSPG2 →	+0.616	+0.082	<.001	.002	3	9
UCEC	JCAD →	+0.584	+0.110	<.001	<.001	3	9
LSCC	TLN1_S1164 →	+0.631	+0.116	<.001	<.001	3	9
UCEC	SVIL →	+0.644	+0.125	<.001	<.001	3	8
GBM	GULP1 →	+0.505	+0.063	.007	.003	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900748 vs SMOC2 — CCRCC

Explore this scatter interactively →