Positive regulation of vascular endothelial growth factor signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of vascular endothelial growth factor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LY6G5B, MTPN, and ID2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of vascular endothelial growth factor signaling pathway activity versus LY6G5B in STOMACH (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	LY6G5B →	+1.099	+0.431	.003	.007	3	6
BONE	MTPN →	+1.133	+0.409	<.001	.003	3	5
BREAST	ID2 →	+2.123	+0.314	<.001	<.001	3	5
BLOOD_Myeloma	HSH2D →	-4.477	-0.326	<.001	.004	3	4
LARGE_INTESTINE	BAIAP2 →	-0.893	-0.236	.008	<.001	3	4
LARGE_INTESTINE	PRR36 →	-0.649	-0.201	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900748 vs LY6G5B — STOMACH

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