Regulation of p38MAPK cascade

Across TCGA patient cohorts, RNA activity of the Regulation of p38MAPK cascade pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ABI3, ANKRD44, and SKAP2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of p38MAPK cascade activity versus ABI3 in LSCC (Pearson r = 0.56).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ABI3 →	+0.461	+0.072	<.001	<.001	3	10
LSCC	ANKRD44 →	+0.501	+0.089	<.001	<.001	3	10
OV	SKAP2 →	+0.686	+0.047	<.001	<.001	3	9
UCEC	WIPF1 →	+0.403	+0.053	<.001	<.001	3	9
CCRCC	ADA2 →	+0.544	+0.034	<.001	<.001	3	9
UCEC	CCDC88B →	+0.514	+0.050	<.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900744 vs ABI3 — LSCC

Explore this scatter interactively →