Regulation of p38MAPK cascade

Across TCGA patient cohorts, RNA activity of the Regulation of p38MAPK cascade pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DAPP1, GNLY, and MT2A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of p38MAPK cascade activity versus DAPP1 in UCEC (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DAPP1 →	+1.036	+0.254	<.001	.001	3	7
COAD	GNLY →	+1.146	+0.277	<.001	<.001	3	6
OV	MT2A →	+1.210	+0.331	<.001	<.001	3	6
LSCC	AMPD3 →	+0.680	+0.727	<.001	<.001	3	6
BRCA	TLR2 →	+0.769	+0.768	<.001	<.001	3	6
LSCC	PIK3R5 →	+0.722	+0.566	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900744 vs DAPP1 — UCEC

Explore this scatter interactively →