Regulation of p38MAPK cascade

Across TCGA cell cohorts, RNA activity of the Regulation of p38MAPK cascade pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBTB20, PLS1, and INPP5D, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZBTB20 grouped by Regulation of p38MAPK cascade-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ZBTB20 →	-0.196	-0.395	.003	.001	3	4
LUNG_NSCLC_LUAD	PLS1 →	-0.079	-0.375	.003	.004	3	4
SKIN	INPP5D →	+0.129	+0.216	.004	.003	3	4
LARGE_INTESTINE	CDH1 →	-0.155	-0.454	.009	.008	2	5
CNS	PFKFB3 →	-0.159	-0.886	.008	.001	3	3
STOMACH	GRK5 →	-0.233	-0.540	.004	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZBTB20 by Regulation of p38MAPK cascade activity — STOMACH

Explore this box plot interactively →