Regulation of p38MAPK cascade

Across TCGA cell cohorts, RNA activity of the Regulation of p38MAPK cascade pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TOR1AIP1, C1orf43, and PTPRF, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of p38MAPK cascade activity versus TOR1AIP1 in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	TOR1AIP1 →	-0.711	-0.329	.005	.001	3	5
LIVER	C1orf43 →	-0.702	-0.457	.007	.001	3	4
KIDNEY	PTPRF →	+2.282	+0.219	.007	.008	3	4
BLOOD_Leukemia	UGCG →	+0.830	+0.172	.009	.002	3	4
SKIN	PEX19 →	-0.638	-0.853	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	COQ10B →	-0.731	-0.359	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900744 vs TOR1AIP1 — UPPER_AERODIGESTIVE_TRACT

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