Regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of phospholipase C-activating G protein-coupled receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RAB11FIP5, DNM1, and NADK_S46, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of phospholipase C-activating G protein-coupled receptor signaling pathway activity versus RAB11FIP5 in LSCC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RAB11FIP5 →	+0.267	+0.065	<.001	.005	3	6
GBM	DNM1 →	+0.682	+0.131	<.001	<.001	3	6
LSCC	NADK_S46 →	-0.497	-0.072	.002	<.001	3	6
LSCC	ARRB2 →	-0.187	-0.068	<.001	<.001	3	5
GBM	GDI1 →	+0.295	+0.123	<.001	<.001	3	5
GBM	SASH3 →	-0.395	-0.089	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900736 vs RAB11FIP5 — LSCC

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