Regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of phospholipase C-activating G protein-coupled receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RGS2, MARCHF4, and PRDM8, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of phospholipase C-activating G protein-coupled receptor signaling pathway activity versus RGS2 in OVARY (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RGS2 →	+2.626	+0.177	<.001	<.001	2	13
LUNG_SCLC	MARCHF4 →	+2.297	+0.145	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	PRDM8 →	+1.053	+0.159	.001	<.001	3	4
OVARY	SMPDL3B →	-1.186	-0.286	.008	.007	3	4
LUNG_SCLC	ZNF703 →	+1.197	+0.090	.004	.007	3	4
LUNG_SCLC	PRKD1 →	+0.985	+0.083	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900736 vs RGS2 — OVARY

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