Regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of phospholipase C-activating G protein-coupled receptor signaling pathway pathway is significantly associated with the drug response of multiple features, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are CI-1040, Axitinib, and Vismodegib, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CI-1040 grouped by Regulation of phospholipase C-activating G protein-coupled receptor signaling pathway-low versus -high activity in LUNG_SCLC.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CI-1040 →	-0.682	-0.382	.010	.002	3	1
LUNG_SCLC	Axitinib →	-1.123	-0.326	.027	.006	3	1
LUNG_SCLC	Vismodegib →	-0.534	-0.418	.032	.002	3	1
LUNG_SCLC	BX795 →	-0.795	-0.300	.007	.032	3	1
LUNG_SCLC	HG-5-88-01 →	-0.600	-0.455	.008	.024	3	1
LUNG_SCLC	CCT245232 →	-0.808	-0.354	.011	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CI-1040 by Regulation of phospholipase C-activating G protein-coupled receptor signaling pathway activity — LUNG_SCLC

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