Acetate ester metabolic process

pathway activity — cross-omics
GO:1900619Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Acetate ester metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC44A4, GOLM1, and SGSM3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUADSLC44A4 →+1.220+0.251<.001.00836
UCECGOLM1 →+0.745+0.228<.001.00635
BRCASGSM3 →+0.463+0.272<.001<.00135
BRCACOG1 →+0.262+0.282<.001<.00135
BRCAAGR2 →+1.128+0.280<.001<.00135
BRCAPDXDC1 →+0.522+0.356<.001.00135
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration