Acetate ester metabolic process

pathway activity — cross-omics
GO:1900619Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Acetate ester metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AQP3, LINC00852, and POU2F2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
PDACAQP3 →+1.583+1.430.002<.00133
LUADLINC00852 →-0.339-0.505.003.00233
GBMPOU2F2 →-0.607-0.248.008.00133
HNSCBMP5 →+0.697+0.113.006.00132
HNSCWEE1 →-1.009-0.113.004.00132
HNSCRNU6-552P →+1.561+0.113<.001.00132
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration