Positive regulation of long-term synaptic depression

Across TCGA patient cohorts, RNA activity of the Positive regulation of long-term synaptic depression pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PABPC3, SMIM8, and SLC25A5P7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of long-term synaptic depression activity versus PABPC3 in OV (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PABPC3 →	+1.075	+0.172	.006	.006	3	5
PDAC	SMIM8 →	-0.248	-0.362	<.001	.004	3	4
LUAD	SLC25A5P7 →	+0.163	+0.670	.001	<.001	3	4
OV	ALDOAP2 →	+0.641	+0.152	.007	.004	3	4
GBM	SEPTIN3 →	+0.846	+0.368	<.001	<.001	3	3
GBM	SNTA1 →	+0.981	+0.404	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900454 vs PABPC3 — OV

Explore this scatter interactively →