Positive regulation of long-term synaptic depression

Across TCGA cell cohorts, RNA activity of the Positive regulation of long-term synaptic depression pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF4A, CYHR1, and TRAPPC9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KIF4A grouped by Positive regulation of long-term synaptic depression-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	KIF4A →	-0.835	-1.256	<.001	.004	3	5
BREAST	CYHR1 →	+0.620	+0.860	.007	<.001	3	4
LUNG_SCLC	TRAPPC9 →	+1.611	+1.639	<.001	<.001	3	4
LUNG_NSCLC_LUAD	SLC2A1 →	-1.436	-0.887	.004	.001	3	4
LUNG_NSCLC_LUAD	DNPEP →	-0.597	-0.727	.002	.001	3	4
LUNG_NSCLC_LUAD	EIF2AK4 →	-0.790	-0.681	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KIF4A by Positive regulation of long-term synaptic depression activity — STOMACH

Explore this box plot interactively →