Regulation of long-term synaptic depression

Across TCGA cell cohorts, RNA activity of the Regulation of long-term synaptic depression pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TEAD1, MRPL38, and ZKSCAN3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TEAD1 grouped by Regulation of long-term synaptic depression-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TEAD1 →	+0.244	+1.107	.004	<.001	3	5
LIVER	MRPL38 →	-0.426	-1.564	.003	.002	3	4
CNS	ZKSCAN3 →	+0.262	+1.289	.001	.006	3	3
BREAST	BAG2 →	-0.140	-1.114	.004	<.001	3	3
BREAST	NUDT12 →	-0.154	-1.339	.004	<.001	3	3
LUNG_NSCLC_LUSC	RHEBL1 →	+0.324	+1.611	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TEAD1 by Regulation of long-term synaptic depression activity — BREAST

Explore this box plot interactively →