Regulation of long-term synaptic depression

Across TCGA cell cohorts, RNA activity of the Regulation of long-term synaptic depression pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GRAMD2B, SMURF2, and ARHGAP23, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of long-term synaptic depression activity versus GRAMD2B in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	GRAMD2B →	+1.010	+1.266	.003	.001	3	7
LIVER	SMURF2 →	+1.880	+1.839	.008	<.001	3	7
BREAST	ARHGAP23 →	+2.580	+1.120	<.001	<.001	3	6
LIVER	NNMT →	+6.076	+1.775	<.001	<.001	3	6
LIVER	ITGA3 →	+5.577	+1.865	<.001	<.001	3	6
PANCREAS	CD83 →	+1.568	+1.576	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900452 vs GRAMD2B — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →