Regulation of glutamate receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of glutamate receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DIPK2B, CLEC1A, and S1PR1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of glutamate receptor signaling pathway activity versus DIPK2B in CCRCC (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	DIPK2B →	+1.188	+1.141	<.001	<.001	3	8
CCRCC	CLEC1A →	+0.620	+0.703	<.001	<.001	3	8
CCRCC	S1PR1 →	+0.680	+0.713	<.001	<.001	3	8
CCRCC	CLEC14A →	+1.414	+1.088	<.001	<.001	3	7
CCRCC	CDH5 →	+1.092	+1.048	<.001	<.001	3	7
CCRCC	ARHGEF15 →	+0.916	+0.999	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900449 vs DIPK2B — CCRCC

Explore this scatter interactively →