Regulation of glutamate receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of glutamate receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STX5, JUN, and SNX10, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of glutamate receptor signaling pathway activity versus STX5 in KIDNEY (Pearson r = 0.85).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	STX5 →	+0.890	+1.965	.003	<.001	3	3
KIDNEY	JUN →	+1.338	+1.888	<.001	<.001	3	3
URINARY_TRACT	SNX10 →	-3.626	-1.926	.004	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	MZT2B →	+0.668	+1.320	<.001	<.001	3	2
UPPER_AERODIGESTIVE_TRACT	ZNF668 →	+0.548	+1.253	.008	.001	3	2
KIDNEY	CAV3 →	+0.108	+1.888	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900449 vs STX5 — KIDNEY

Explore this scatter interactively →