Regulation of defense response to bacterium

Across TCGA cell cohorts, RNA activity of the Regulation of defense response to bacterium pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C3AR1, SLC35A1, and CLIC4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C3AR1 grouped by Regulation of defense response to bacterium-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	C3AR1 →	+0.943	+0.586	<.001	.001	3	5
URINARY_TRACT	SLC35A1 →	-1.103	-1.296	.001	.001	3	4
BREAST	CLIC4 →	+1.426	+0.992	.004	.001	3	4
CNS	HSD17B11 →	-0.892	-0.728	.005	.002	3	4
BONE	TENT2 →	+0.672	+1.342	.009	.009	3	4
BREAST	RHBG →	-1.168	-0.968	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C3AR1 by Regulation of defense response to bacterium activity — CNS

Explore this box plot interactively →