Negative regulation of secondary metabolite biosynthetic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of secondary metabolite biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP26, LAD1, and ARHGAP27, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARHGAP26 grouped by Negative regulation of secondary metabolite biosynthetic process-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ARHGAP26 →	-1.661	-1.224	<.001	.002	3	6
STOMACH	LAD1 →	-4.308	-1.840	.005	<.001	3	5
STOMACH	ARHGAP27 →	-1.684	-1.268	.005	.001	2	6
LARGE_INTESTINE	KRT8 →	-2.461	-0.786	.005	.009	2	6
BLOOD_Leukemia	ADAP1 →	-2.659	-1.540	.005	<.001	2	6
BREAST	SOWAHB →	-0.964	-1.058	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARHGAP26 by Negative regulation of secondary metabolite biosynthetic process activity — STOMACH

Explore this box plot interactively →