Negative regulation of long-term synaptic potentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of long-term synaptic potentiation pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VCL, AIMP1, and MARK1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of long-term synaptic potentiation activity versus VCL in CCRCC (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	VCL →	+0.511	+0.070	<.001	<.001	3	7
CCRCC	AIMP1 →	-0.117	-0.070	<.001	<.001	3	6
CCRCC	MARK1 →	+0.479	+0.067	.002	<.001	3	6
GBM	RPL5 →	-0.264	-0.094	<.001	<.001	3	6
COAD	TLN1 →	+0.322	+0.042	<.001	<.001	3	6
COAD	EHD2 →	+0.512	+0.042	.004	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900272 vs VCL — CCRCC

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