Negative regulation of long-term synaptic potentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of long-term synaptic potentiation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KRT8P25, SIGLEC10, and RNA5SP383, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of long-term synaptic potentiation activity versus KRT8P25 in GBM (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	KRT8P25 →	-0.020	-0.225	.004	<.001	3	3
BRCA	SIGLEC10 →	+0.551	+0.200	.002	.003	3	3
LUAD	RNA5SP383 →	+0.579	+0.390	.007	.005	3	3
LUAD	COL23A1 →	+0.283	+0.345	.006	<.001	3	3
PDAC	PRKG2 →	-0.440	-0.581	.005	.007	3	2
PDAC	ACTL10 →	-0.147	-0.627	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900272 vs KRT8P25 — GBM

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