Negative regulation of long-term synaptic potentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of long-term synaptic potentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GTF2H1, PSMA1, and AOX1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GTF2H1 grouped by Negative regulation of long-term synaptic potentiation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GTF2H1 →	-0.424	-0.517	.001	.004	3	4
LUNG_NSCLC_LUAD	PSMA1 →	-0.529	-0.645	.003	.002	3	4
LUNG_NSCLC_LUAD	AOX1 →	-1.480	-0.987	.003	<.001	3	4
LUNG_NSCLC_LUAD	NEIL2 →	-0.643	-0.533	.001	.002	3	4
LUNG_NSCLC_LUAD	FSTL3 →	-1.913	-0.889	<.001	<.001	3	4
CNS	TIAM1 →	+1.334	+1.067	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GTF2H1 by Negative regulation of long-term synaptic potentiation activity — LUNG_NSCLC_LUAD

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