Negative regulation of long-term synaptic potentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of long-term synaptic potentiation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRNP, UBQLNL, and KMT5B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of long-term synaptic potentiation activity versus PRNP in SOFT_TISSUE (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PRNP →	+2.022	+0.344	.001	.006	3	4
SOFT_TISSUE	UBQLNL →	+0.261	+0.349	<.001	.005	3	4
BLOOD_Leukemia	KMT5B →	+0.603	+0.797	<.001	.006	3	4
LUNG_NSCLC_LUSC	ANTKMT →	-0.883	-0.370	<.001	<.001	3	4
LUNG_NSCLC_LUSC	GOLGA8B →	-1.017	-0.343	.003	.001	3	4
BREAST	HBEGF →	+1.266	+0.277	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900272 vs PRNP — SOFT_TISSUE

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