Regulation of long-term synaptic potentiation

Across TCGA patient cohorts, RNA activity of the Regulation of long-term synaptic potentiation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP2_T290, SORBS1, and DKC1_S494, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of long-term synaptic potentiation activity versus MAP2_T290 in BRCA (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MAP2_T290 →	+0.795	+0.034	.004	.006	3	5
OV	SORBS1 →	+0.487	+0.031	.002	.006	3	4
BRCA	DKC1_S494 →	-0.354	-0.032	.005	.001	3	4
CCRCC	FBLIM1 →	+0.356	+0.031	.003	<.001	3	4
GBM	SIRPA →	+0.334	+0.033	.005	.004	3	4
GBM	TMOD2 →	+0.364	+0.047	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900271 vs MAP2_T290 — BRCA

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