Regulation of long-term synaptic potentiation

Across TCGA patient cohorts, RNA activity of the Regulation of long-term synaptic potentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDIT4L, ATP5PF, and SMR3A, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of long-term synaptic potentiation activity versus DDIT4L in LUAD (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DDIT4L →	+1.414	+0.523	<.001	.002	3	3
LUAD	ATP5PF →	+0.343	+0.409	.001	.003	3	3
HNSC	SMR3A →	+0.423	+0.237	.006	.005	3	2
HNSC	P2RY12 →	+0.587	+0.372	.002	.003	2	3
COAD	EPB42 →	-0.032	-0.356	.001	<.001	3	2
COAD	RN7SL482P →	-0.090	-0.567	.007	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900271 vs DDIT4L — LUAD

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