Regulation of long-term synaptic potentiation

Across TCGA cell cohorts, RNA activity of the Regulation of long-term synaptic potentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLDN7, SLC25A25, and TSG101, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CLDN7 grouped by Regulation of long-term synaptic potentiation-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CLDN7 →	+3.748	+1.279	.008	.004	3	4
SKIN	SLC25A25 →	-0.570	-1.027	.006	.009	3	4
STOMACH	TSG101 →	-0.935	-1.331	.001	<.001	3	4
CNS	CEP57L1 →	-0.631	-1.061	.002	.001	3	4
BREAST	GUCA1A →	+0.016	+0.863	.002	<.001	3	4
LUNG_SCLC	GNB3 →	+1.742	+1.111	.006	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CLDN7 by Regulation of long-term synaptic potentiation activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →