Regulation of long-term synaptic potentiation

Across TCGA cell cohorts, RNA activity of the Regulation of long-term synaptic potentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDKN3, SRP54, and FAM177A1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of long-term synaptic potentiation activity versus CDKN3 in BLOOD_Leukemia (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CDKN3 →	+0.813	+0.970	<.001	<.001	3	4
LUNG_SCLC	SRP54 →	+0.795	+0.241	.001	.001	3	4
OVARY	FAM177A1 →	+1.050	+0.284	<.001	<.001	3	4
BLOOD_Leukemia	ZDHHC18 →	+0.454	+0.706	.007	.001	3	4
BLOOD_Myeloma	CFAP44 →	-1.116	-0.204	<.001	.005	3	4
BLOOD_Leukemia	CDC7 →	+0.742	+0.770	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900271 vs CDKN3 — BLOOD_Leukemia

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