Positive regulation of RIG-I signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of RIG-I signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZC3HAV1, MAP1LC3B2, and CLK2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of RIG-I signaling pathway activity versus ZC3HAV1 in BLOOD_Lymphoma (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ZC3HAV1 →	+1.218	+1.111	<.001	<.001	3	6
BLOOD_Leukemia	MAP1LC3B2 →	+0.516	+0.710	.009	.003	3	5
LARGE_INTESTINE	CLK2 →	-0.595	-0.619	.004	.009	3	5
BREAST	HILPDA →	-1.591	-1.102	<.001	<.001	3	4
BONE	TSSK4 →	-0.812	-1.486	.005	<.001	3	4
STOMACH	TRAK1 →	-1.414	-1.120	.009	.005	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900246 vs ZC3HAV1 — BLOOD_Lymphoma

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