Positive regulation of synaptic vesicle endocytosis

Across TCGA patient cohorts, RNA activity of the Positive regulation of synaptic vesicle endocytosis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLEC4D, IL18RAP, and CD72, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of synaptic vesicle endocytosis activity versus CLEC4D in LSCC (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CLEC4D →	+0.588	+0.630	<.001	<.001	3	5
LSCC	IL18RAP →	+0.684	+0.867	<.001	<.001	3	5
LSCC	CD72 →	+0.502	+0.661	<.001	<.001	3	5
LSCC	ICOS →	+0.636	+0.726	<.001	<.001	3	5
LSCC	CXCL3 →	+1.017	+0.624	<.001	<.001	3	5
LSCC	CLEC4E →	+0.901	+0.837	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900244 vs CLEC4D — LSCC

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